GRANULATION USING THE AGGLOMERATIVE PHASE OF COMMINUTION

被引:18
作者
HO, T [1 ]
HERSEY, JA [1 ]
机构
[1] INST DRUG TECHNOL LTD,PARKVILLE 3052,VICTORIA,AUSTRALIA
关键词
D O I
10.1016/0032-5910(79)87006-0
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Aggregation and agglomeration have been extensively reported in the literature during the prolonged milling of powders. This phase is usually considered non-productive and is delayed by the use of grinding aids. The agglomeration phase of sucrose, sodium chloride, lactose and paracetamol has been studied as a possible method of producing pharmaceutical granules. In this paper the mechanism of agglomeration at the particulate level is examined. It is shown, that following particle size reduction, there is agglomeration of the fine coherent particles into a loose granular structure. This granule is then either compressed into a harder granule or remilled to produce fine powder. Finally, an equilibrium between size reduction and agglomeration is attained. © 1979.
引用
收藏
页码:191 / 195
页数:5
相关论文
共 32 条
  • [31] WORTS O, 1972, PHARM IND, V34, P820
  • [32] 1975, HDB CHEM PHYSICS