SEQUENCE SIMILARITY BETWEEN OPIOID PEPTIDE PRECURSORS AND DNA-BINDING PROTEINS

被引：15

作者：

BAKALKIN, GY ^{[1
]}

PONOMARIEV, D ^{[1
]}

SARKISYAN, RA ^{[1
]}

TERENIUS, L ^{[1
]}

机构：

[1] NATL CARDIOL RES CTR,MOSCOW 121552,USSR

来源：

FEBS LETTERS | 1991年 / 282卷 / 01期

关键词：

OPIOID PRECURSOR; DNA-BINDING PROTEIN; SEQUENCE HOMOLOGY;

D O I：

10.1016/0014-5793(91)80471-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The opioid peptide precursors, preprodynorphin and preproenkephalin show structure similarity with a transcription factor, hunchback and the putative helix-loop-helix DNA-binding proteins, lil-1, tal and twist. Segments with similarity contain the three enkephalin sequences in preprodynorphin and one in preproenkephalin which are present within heptapeptide repeats characteristic of an alpha-helical coiled-coil structure distinctive of an amphipathic helix-loop-helix DNA-binding motif. Hunchback and the opioid prohormones also have cystein-rich regions characteristic of zinc-finger domains in common.

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收藏

页码：175 / 177

页数：3

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