EXTRACTIONLESS HPLC METHOD FOR THE DETERMINATION OF NAPROXEN IN HUMAN PLASMA AND URINE

被引：21

作者：

KARIDAS, T

AVGERINOS, A

MALAMATARIS, S

机构：

[1] Laboratory of Pharmaceutical Technology, University of Thessaloniki

来源：

ANALYTICAL LETTERS | 1993年 / 26卷 / 11期

关键词：

NAPROXEN; HPLC; HUMAN PLASMA AND URINE;

D O I：

10.1080/00032719308017474

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple and rapid (extractionless) high-performance liquid chromatographic method with ultraviolet detection, at 278 nm, is described for the determination of naproxen in human plasma and urine. Niflumic acid is used as internal standard. The chromatographic system consists of a reversed-phase C18-Spherisorb column with acetonitrile/0.1 M sodium acetate (35:65 v/v, pH 6.14) as the mobile phase. The retention time is 3.0 min for naproxen and 3.8 min for niflumic acid. The total run time is 5 min and the typical assay time is 10 min. The method is sufficiently sensitive for biopharmaceutical studies, after the oral administration of a single sustained release dose.

引用

页码：2341 / 2348

页数：8

共 20 条

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