INVITRO TRANSFORMATION BY THE SV40 EARLY REGION OF CELLS FROM A HUMAN BENIGN SALIVARY-GLAND TUMOR WITH A 12Q13-]Q15 REARRANGEMENT

被引：33

作者：

KAZMIERCZAK, B

BARTNITZKE, S

HARTL, M

BULLERDIEK, J

机构：

[1] UNIV BREMEN,CTR HUMAN GENET,LEOBENER STR NW2,W-2800 BREMEN 33,GERMANY

[2] UNIV MUNICH,INST BIOCHEM,W-8000 MUNICH 2,GERMANY

来源：

CYTOGENETICS AND CELL GENETICS | 1990年 / 53卷 / 01期

关键词：

D O I：

10.1159/000132891

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells from a salivary gland pleomorphic adenoma with a reciprocal translocation. t(8:12)(q22;ql4). were transformed by transfection with a plasmid containing the SV40 “early region.” Compared with nontransformed adenoma cells, the cells expressed large-T antigen, had a higher proliferative capacity. showed a drastically increased or even unlimited growth potential in vitro, and formed colonies in soft agar. The amount of cellular material produced in this way should make possible many experiments at the molecular level that could not be performed before. © 1990 S. Karger AG, Basel.

引用

页码：37 / 39

页数：3

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