HETEROCYCLIC SUBSTITUTED UREAS .2. IMMUNOSUPPRESSIVE AND ANTIVIRAL ACTIVITY OF BENZOTHIAZOLE- AND BENZOXAZOLEUREAS

被引：119

作者：

PAGET, CJ

KISNER, K

STONE, RL

DELONG, DC

机构：

[1] Lilly Research Loboratories, Eli Lilly and Company, Indianapolis, Indiana

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 06期

关键词：

D O I：

10.1021/jm00306a011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-activity relationship at the previously reported immunosuppressive and antiviral benzimidazoleureas has been extended to the analogous benzothiazole- and benzoxazoleureas. The most potent series of immunosuppressant compounds was the 1-(2-naphtho[2,1-d]thiazolyl)-3-substitutcd ureas, one member of which was 250 times as active as azathioprine in the sheep erythrocyte test in mice. © 1969, American Chemical Society. All rights reserved.

引用

页码：1016 / &

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