DEOXYRIBONUCLEIC-ACID STRUCTURES VISUALIZED BY SCANNING TUNNELING MICROSCOPY

被引:15
作者
BENDIXEN, C [1 ]
BESENBACHER, F [1 ]
LAEGSGAARD, E [1 ]
STENSGAARD, I [1 ]
THOMSEN, B [1 ]
WESTERGAARD, O [1 ]
机构
[1] AARHUS UNIV,INST PHYS,DK-8000 AARHUS C,DENMARK
来源
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS | 1990年 / 8卷 / 01期
关键词
D O I
10.1116/1.576987
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The capability of the scanning tunneling microscope (STM) to produce atomic-resolution images makes it a powerful tool in both basic and applied science. The main application of STM has been for the analysis of structural features and electronic properties of a wide spectrum of metals and semiconductors, while only a few biological items have been investigated. With a STM operating in air at ambient pressure, we present images showing the molecular structure of naked DNA. High-resolution topographic images of linear DNA fragments reveal structures with a periodicity of ~ 38 ± 6 A and a width of 28 + 4 A, consistent with the molecular dimensions of the helical repeat of double-stranded DNA. In addition, the supreme resolving power of the STM permits visualization of the major and minor grooves. © 1990, American Vacuum Society. All rights reserved.
引用
收藏
页码:703 / 705
页数:3
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