SYNTHESIS AND ANTIFUNGAL ACTIVITY OF PRADIMICIN DERIVATIVES - MODIFICATIONS ON THE AGLYCONE PART

被引：16

作者：

ABURAKI, S

OKUYAMA, S

HOSHI, H

KAMACHI, H

NISHIO, M

HASEGAWA, T

MASUYOSHI, S

IIMURA, S

KONISHI, M

OKI, T

机构：

[1] Bristol-Myers Squibb Research Institute, Bristol-Myers Squibb K. K., 2-9-3 Shimo-meguro, Meguro-ku

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 09期

关键词：

D O I：

10.7164/antibiotics.46.1447

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Synthesis and antifungal activity of pradimicin analogs modified on the aglycone part is described. Upon modification studies at various sites of the aglycone part using pradimicin A (PRM A), C-11 position was found to be the sole site to be modified without loosing antifungal activity. Further modification studies at C-11 position were carried out with 11-OH derivative of pradimicin T1 (PRM T1) because of its easy availability. Among the compounds prepared, 11-demethoxy derivative of PRM A (12) and 11-O-ethyl (13) and 11-O-fluoroethyl (14) derivatives of PRM T1 showed promising antifungal activity comparable to that of PRM A.

引用

页码：1447 / 1457

页数：11

共 8 条

[1] SYNTHESIS AND ANTIFUNGAL ACTIVITY OF PRADIMICIN DERIVATIVES - MODIFICATIONS OF THE SUGAR PART [J].