AMYLIN GIVEN BY CENTRAL AND PERIPHERAL ROUTES INHIBITS ACID GASTRIC-SECRETION

被引：44

作者：

GUIDOBONO, F

COLUZZI, M

PAGANI, F

PECILE, A

NETTI, C

机构：

[1] Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, 20129 Milan

来源：

PEPTIDES | 1994年 / 15卷 / 04期

关键词：

AMYLIN; ACID GASTRIC SECRETION; PYLORUS LIGATION;

D O I：

10.1016/0196-9781(94)90098-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of rat amylin on acid gastric secretion in the pylorus-ligated, unanesthetized rat system (Shay test) was examined. Amylin administered peripherally (2.5, 5, 10, 40, 100, or 160 mu g/kg, SC) or intracerebroventricularly (1.5, 2.7, or 5 mu g/rat, ICV) decreased acid gastric secretion in a dose-dependent manner. Central administration of amylin gave a stronger suppression of gastric secretion than peripheral injection. In addition, ICV-injected amylin inhibited insulin-stimulated acid gastric secretion and was effective in suppressing acid gastric secretion in rats depleted of somatostatin by pretreatment with cysteamine. This study suggests that amylin may participate in the central regulation of acid gastric secretion and indicates a possible biological function of amylin as a gastrointestinal peptide.

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收藏

页码：699 / 702

页数：4

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