ANOREXIA FOLLOWING THE INTRAHYPOTHALAMIC ADMINISTRATION OF AMYLIN

被引：161

作者：

CHANCE, WT

BALASUBRAMANIAM, A

ZHANG, FS

WIMALAWANSA, SJ

FISCHER, JE

机构：

[1] VET AFFAIRS MED CTR,CINCINNATI,OH

[2] UNIV LONDON,HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT CHEM PATHOL,LONDON,ENGLAND

来源：

BRAIN RESEARCH | 1991年 / 539卷 / 02期

关键词：

FEEDING; ANOREXIA; DOPAMINE; SEROTONIN; AMYLIN; DIABETES-ASSOCIATED PEPTIDE; CALCITONIN GENE-RELATED PEPTIDE;

D O I：

10.1016/0006-8993(91)91644-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The intrahypothalamic injection of rat amylin reduced feeding in schedule-fed rats for eight hours. Specificity of this anorectic response was indicated by an appropriate dose-response relationship and the absence of effect of human amylin. Amylin-induced anorexia was accompanied by alterations in neurotransmitter metabolism similar to those observed in anorectic tumor-bearing rats. These results indicate that amylin may inhibit feeding by acting directly on hypothalamic neurons to alter metabolism of neurotransmitter systems known to affect feeding behavior.

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收藏

页码：352 / 354

页数：3

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