A GENETIC-ANALYSIS OF RELATIVE WEIGHT AMONG 4,020 TWIN PAIRS, WITH AN EMPHASIS ON SEX EFFECTS

被引：35

作者：

ALLISON, DB

HESHKA, S

NEALE, MC

LYKKEN, DT

HEYMSFIELD, SB

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,ST LUKES ROOSEVELT HOSP,OBES RES CTR,NEW YORK,NY 10032

[2] UNIV MINNESOTA,DEPT PSYCHOL,MINNEAPOLIS,MN 55455

[3] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT HUMAN GENET,RICHMOND,VA 23298

来源：

HEALTH PSYCHOLOGY | 1994年 / 13卷 / 04期

关键词：

OBESITY; GENETICS; TWINS; SEX LIMITATION;

D O I：

10.1037/0278-6133.13.4.362

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

This study replicated previous findings showing a high heritability of obesity, as measured by body mass index (kg/m2), using a measure of relative weight that does not assume a constant regression of height on weight across different populations, and evaluated whether there are sex-limited genetic effects. Subjects were 4,020 adult twin pairs. Alternative causal structural equation models were fitted to variance-covariance matrices. The ADE model (additive genetic effects, dominant/nonadditive genetic effects, and unique environment) fit best. Allowing for sex-specific effects (common sex-limitation model) significantly improved the fit, X2(6) = 230.5, p <.001. The heritability of that portion of weight unrelated to height was large: .61 for men and .73 for women.

引用

页码：362 / 365

页数：4

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