10-PROPARGYLAMINOPTERIN AND ALKYL HOMOLOGS OF METHOTREXATE AS INHIBITORS OF FOLATE METABOLISM

被引：22

作者：

PIPER, JR

MCCALEB, GS

MONTGOMERY, JA

KISLIUK, RL

GAUMONT, Y

SIROTNAK, FM

机构：

[1] MEM SLOAN KETTERING CANC CTR, NEW YORK, NY 10021 USA

[2] TUFTS UNIV, SCH MED, DEPT BIOCHEM & PHARMACOL, BOSTON, MA 02111 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1982年 / 25卷 / 07期

关键词：

D O I：

10.1021/jm00349a024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：877 / 880

页数：4

共 12 条

[1] REDUCED DERIVATIVES OF METHOTREXATE
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[2] A POTENT ANTI-TUMOR QUINAZOLINE INHIBITOR OF THYMIDYLATE SYNTHETASE - SYNTHESIS, BIOLOGICAL PROPERTIES AND THERAPEUTIC RESULTS IN MICE
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[J]. EUROPEAN JOURNAL OF CANCER, 1981, 17 (01) : 11 - 19
[3] KISLIUK RL, 1974, J BIOL CHEM, V249, P4100
[4] FOLATE ANALOGS ALTERED IN THE C-9-N-10 BRIDGE REGION .18. SYNTHESIS AND ANTI-TUMOR EVALUATION OF 11-OXAHOMOAMINOPTERIN AND RELATED-COMPOUNDS
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[5] SYNTHESES OF ALPHA-SUBSTITUTED AND GAMMA-SUBSTITUTED AMIDES, PEPTIDES, AND ESTERS OF METHOTREXATE AND THEIR EVALUATION AS INHIBITORS OF FOLATE METABOLISM
PIPER, JR
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[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (02) : 182 - 187
[6] SYNTHESES OF SOME ANALOGS OF A POSSIBLE INTERMEDIATE FORMED IN THYMIDYLATE SYNTHETASE REACTION
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[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1967, 4 (04) : 475 - &
[7] SIROTNAK FM, 1976, CANCER RES, V36, P1151
[8] ANALOG SPECIFIC ABERRANCIES IN ANTIFOLATE INHIBITION OF L1210 CELL DIHYDROFOLATE-REDUCTASE
SIROTNAK, FM
CHELLO, PL
MOCCIO, DM
PIPER, JR
MONTGOMERY, JA
PARHAM, JC
[J]. BIOCHEMICAL PHARMACOLOGY, 1980, 29 (24) : 3293 - 3298
[9] SIROTNAK FM, 1976, CANCER RES, V36, P4672
[10] CORRELATES OF FOLATE ANALOG TRANSPORT, PHARMACOKINETICS AND SELECTIVE ANTI-TUMOR ACTION
SIROTNAK, FM
[J]. PHARMACOLOGY & THERAPEUTICS, 1980, 8 (01) : 71 - 103

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