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DNA-SYNTHESIS IN THE PITUITARY-GLAND OF THE RAT - EFFECT OF SULPIRIDE AND CLOMIPHENE

被引：16
作者：
BURDMAN, JA
SZIJAN, I
JAHN, GA
MACHIAVELLI, G
KALBERMANN, LE
机构：
[1] Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires
来源：
EXPERIENTIA | 1979年 / 35卷 / 09期
关键词：
D O I：
10.1007/BF01963324
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sulpiride administration to rats releases prolactin and increases DNA replication in the anterior pituitary gland. Clomiphene prevents the stimulation of DNA synthesis produced by sulpiride, but does not affect prolactin release from the gland. These findings suggest that the intracellular prolactin content of the anterior pituitary gland plays a role in the regulation of DNA synthesis through a mechanism mediated by oestrogens. © 1979 Birkhäuser Verlag.
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页码：1258 / 1259
页数：2
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