THE TREATMENT OF RESISTANT NEUROBLASTOMA WITH I-131 METAIODOBENZYLGUANIDINE - ALTERNATIVE METHODS OF DOSE PRESCRIPTION

被引：13

作者：

FIELDING, SL

FLOWER, MA

ACKERY, DM

KEMSHEAD, J

LASHFORD, LS

LEWIS, IJ

机构：

[1] ROYAL MARSDEN HOSP,LONDON,ENGLAND

[2] INST CANC RES,SUTTON SM2 5PX,SURREY,ENGLAND

[3] SOUTHAMPTON GEN HOSP,DEPT NUCL MED,SOUTHAMPTON SO9 4XY,HANTS,ENGLAND

[4] FRENCHAY HOSP,IMPERIAL CANC RES FUND,PAEDIAT & NEURONCOL GRP,BRISTOL BS16 1LE,AVON,ENGLAND

[5] IMPERIAL CANC RES FUND,LEEDS,ENGLAND

[6] ST JAMES UNIV HOSP,DEPT PAEDIAT ONCOL,LEEDS LS9 7TF,W YORKSHIRE,ENGLAND

[7] UNIV LEICESTER,UNITED KINGDOM CHILDRENS CANC STUDY GRP,NEW AGENTS GRP,LEICESTER LE1 7RH,ENGLAND

来源：

RADIOTHERAPY AND ONCOLOGY | 1992年 / 25卷 / 01期

关键词：

131I-METAIODOBENZYLGUANIDINE; TARGETED RADIONUCLIDE THERAPY; DOSE PRESCRIPTION; NEUROBLASTOMA;

D O I：

10.1016/0167-8140(92)90199-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A UK multi-centre study has been carried out to collect medical and dosimetry data from treatments with I-131-metaiodobenzylguanidine (mIBG) for patients suffering from resistant neuroblastoma. All data have been acquired in a standardised way, following strict physics and clinical protocols. The accuracy of three different methods of dose prescription was studied. The results show that the most accurate method involved the use of an initial tracer study to determine the therapeutic activity required to deliver a predetermined absorbed whole-body (WB) dose.

引用

页码：73 / 76

页数：4

共 9 条

[1]

EVANS AE, 1971, CANCER, V27, P374, DOI 10.1002/1097-0142(197102)27:2<374::AID-CNCR2820270221>3.0.CO

[2]

2-G

[3] DOSIMETRY OF I-131 METAIODOBENZYLGUANIDINE FOR TREATMENT OF RESISTANT NEUROBLASTOMA - RESULTS OF A UK STUDY [J].

FIELDING, SL ;

FLOWER, MA ;

ACKERY, D ;

KEMSHEAD, JT ;

LASHFORD, LS ;

LEWIS, I .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1991, 18 (05) :308-316

[4]

HOEFNAGEL CA, 1988, MOL BIOL GENETICS CH, P112

[5] SYSTEMIC ADMINISTRATION OF RADIONUCLIDES IN NEURO-BLASTOMA AS PLANNED RADIOTHERAPEUTIC INTERVENTION [J].

LASHFORD, LS ;

CLARKE, J ;

KEMSHEAD, JT .

MEDICAL AND PEDIATRIC ONCOLOGY, 1990, 18 (01) :30-36

[6]

LOEVINGER R, 1989, MIRD PRIMER ABSORBED

[7]

TREUNER J, 1988, ADV NEUROBLASTOMA RE, V2, P669

[8]

1983, NCRP73 NAT COUNC RAD, P51

[9]

1987, MED PEDIATR ONCOL, V15, P157

← 1 →