ALTERATIONS IN STRIATAL NEUROTROPHIC ACTIVITY-INDUCED BY DOPAMINERGID DRUGS

被引:17
作者
CARVEY, PM
PTAK, LR
LIN, DH
LO, ES
BUHRFIEND, CM
DRUCKER, GE
FIELDS, JZ
机构
[1] HINES V A HOSP, RES SERV 151, HINES, IL USA
[2] LOYOLA UNIV, MED CTR, DEPT PHARMACOL, MAYWOOD, IL 60153 USA
关键词
TROPHIC FACTOR; DOPAMINE; HALOPERIDOL; LEVODOPA; AMPHETAMINE; CULTURE; REVIEW; STRIATUM;
D O I
10.1016/0091-3057(93)90340-Y
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The administration of dopaminergic drugs induces a variety of compensatory responses ostensibly designed to reinstate normal dopamine (DA) tone. We have hypothesized that drug-induced alterations in striatal-derived neurotrophic activity contributes to these compensatory processes. This phenomenon has been studied by examining the growth of mesencephalic cultures incubated with cell-free extracts of striatal tissue taken from patients or rats treated with various drugs. Our results reveal that reducing striatal DA tone by administering the DA antagonist haloperidol, the DA neurotoxin 6-hydroxydopamine, or as occurs naturally in Parkinson's disease, increases striatal trophic activity. Conversely, increasing striatal DA tone by administering the indirect DA agonists amphetamine or levodopa reduces trophic activity in the striatum. Kainic acid lesions of the striatum similarly reduce this trophic activity. The implications of these drug-induced alterations in trophic activity are discussed and reviewed.
引用
收藏
页码:195 / 204
页数:10
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