INCREASED AMPHETAMINE POTENCY FOLLOWING CHRONIC NALTREXONE ADMINISTRATION IN RATS

被引：11

作者：

AMIR, S

BLAIR, R

AMIT, Z

机构：

[1] Center for Research on Drug Dependence Department of Psychology, Que. H3G 1M8

来源：

LIFE SCIENCES | 1979年 / 25卷 / 16期

关键词：

D O I：

10.1016/0024-3205(79)90418-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chronic administration of the long acting opiate antagonist naltrexone potentiated the amphetamine and apomorphine- -induced stimulation of locomotor activity in rats. Similar treatment also resulted in increased locomotor activity in saline injected rats. The results suggest that chronic opiate receptor blockade may lead to the development of supersensitivity in dopamine systems that mediate motor control. The results provide further support for the notion that endogenous opioids modulate the function of dopamine systems in the brain. © 1979.

引用

页码：1407 / 1412

页数：6

共 46 条

[11] DIAMOND BI, 1978, NEUROLOGY, V28, P1085
[12] IMMUNOHISTOCHEMICAL STUDIES USING ANTIBODIES TO LEUCINE-ENCEPHALIN - INITIAL OBSERVATIONS ON NERVOUS-SYSTEM OF RAT
ELDE, R
HOKFELT, T
JOHANSSON, O
TERENIUS, L
[J]. NEUROSCIENCE, 1976, 1 (04) : 349 - &
[13] OPIATE-RECEPTOR MEDIATED CHANGES IN MONO-AMINE SYNTHESIS IN RAT-BRAIN
GARCIASEVILLA, JA
AHTEE, L
MAGNUSSON, T
CARLSSON, A
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1978, 30 (10) : 613 - 621
[14] NALOXONE BLOCKS AMPHETAMINE-INDUCED REARING - POTENTIAL INTERACTION BETWEEN CATECHOLAMINES AND ENDORPHINS
HABER, S
HATSUKAMI, T
BERGER, PA
BARCHAS, JD
AKIL, H
[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY, 1978, 2 (04): : 425 - 430
[15] BEHAVIORAL INTERACTIONS BETWEEN NALOXONE AND DOPAMINE AGONISTS
HARRIS, RA
SNELL, D
LOH, HH
WAY, EL
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1977, 43 (03) : 243 - 246
[16] HOLTZMAN SG, 1974, J PHARMACOL EXP THER, V189, P51
[17] CHRONIC TREATMENT WITH HALOPERIDOL ACCELERATES BIOSYNTHESIS OF ENKEPHALINS IN RAT STRIATUM
HONG, JS
YANG, HYT
GILLIN, JC
DIGIULIO, AM
FRATTA, W
COSTA, E
[J]. BRAIN RESEARCH, 1979, 160 (01) : 192 - 195
[18] HONG JS, 1978, J PHARMACOL EXP THER, V205, P141
[19] BEHAVIORAL ACTIVATION BY ENKEPHALINS IN MICE
KATZ, RJ
CARROLL, BJ
BALDRIGHI, G
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1978, 8 (04) : 493 - 496
[20] EVIDENCE FOR A RECEPTOR-MEDIATED FEEDBACK CONTROL OF STRIATAL TYROSINE-HYDROXYLASE ACTIVITY
KEHR, W
ATACK, C
CARLSSON, A
MAGNUSSON, T
LINDQVIST, M
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1972, 24 (09) : 744 - +

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