MOLECULAR-BASIS OF LARON DWARFISM

被引：15

作者：

AMSELEM, S ^{[1
]}

DUQUESNOY, P ^{[1
]}

GOOSSENS, M ^{[1
]}

机构：

[1] HENRI MONDOR CENT UNIV HOSP,INSERM,U91,F-94010 CRETEIL,FRANCE

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1991年 / 2卷 / 01期

关键词：

D O I：

10.1016/1043-2760(91)90059-V

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An autosomal recessive disorder, Laron-type dwarfism, results from peripheral unresponsiveness to growth hormone. Mutations in the growth hormone receptor have recently been identified in this syndrome. Analysis of patients with Laron-type dwarfism should provide insight into the mechanisms of hormone receptor binding and signal transduction pathways of this receptor, which belongs to a new class of transmembrane receptors.

引用

页码：35 / 40

页数：6

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