STEREOELECTRONIC INFLUENCE OF FLUORINE IN ENZYME RESOLUTIONS OF ALPHA-FLUOROESTERS

被引：17

作者：

OHAGAN, D ^{[1
]}

RZEPA, HS ^{[1
]}

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT CHEM,LONDON SW7 2AY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1994年 / 01期

关键词：

D O I：

10.1039/p29940000003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The very high enantioselectivity demonstrated by two different lipase enzymes towards alpha-fluoroesters is shown from quantitative PM3 and ab initio 6-31G* SCF-MO calculations to arise from stereoelectronic factors, which are predicted to be reduced when the diastereoisomeric transition states are modelled in the condensed aqueous phase.

引用

页码：3 / 4

页数：2

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