INTERACTION OF DIIODOTHYRONINES WITH ISOLATED CYTOCHROME-C-OXIDASE

被引：69

作者：

GOGLIA, F ^{[1
]}

LANNI, A ^{[1
]}

BARTH, J ^{[1
]}

KADENBACH, B ^{[1
]}

机构：

[1] UNIV MARBURG, FACHBEREICH CHEM, D-35032 MARBURG, GERMANY

来源：

FEBS LETTERS | 1994年 / 346卷 / 2-3期

关键词：

THYROID HORMONE; DIIODOTHYRONINE; CYTOCHROME C OXIDASE; CONFORMATIONAL CHANGE; MITOCHONDRION; OXYGEN UPTAKE;

D O I：

10.1016/0014-5793(94)00476-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diiodothyronines (3,3'-T-2 and 3,5-T-2) stimulate the activity of isolated cytochrome c oxidase (COX) from bovine heart mitochondria. Maximal stimulation of activity (about 50%) is obtained with 3,3'-T-2 at pH 6.4 and with 3,5-T-2 at pH 7.4. In contrast, 3,5,3'-triiodothyronine (T-3) exhibited no or little stimulation of COX activity. Binding of the hormones to COX leads to conformational changes as shown by modified visible spectra of the oxidized enzyme. It is suggested that 'short-term' effects of thyroid hormones on mitochondrial respiration are at least partly due to the allosteric interaction of diiodothyronines with the COX complex.

引用

页码：295 / 298

页数：4

共 26 条

[1] TISSUE-SPECIFIC REGULATION OF BOVINE HEART CYTOCHROME-C-OXIDASE ACTIVITY BY ADP VIA INTERACTION WITH SUBUNIT-VIA [J].

ANTHONY, G ;

REIMANN, A ;

KADENBACH, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) :1652-1656

[2] CONTROL OF ELECTRON FLUX THROUGH THE RESPIRATORY-CHAIN IN MITOCHONDRIA AND CELLS [J].

BRAND, MD ;

MURPHY, MP .

BIOLOGICAL REVIEWS, 1987, 62 (02) :141-193

[3]

FERGUSONMILLER S, 1976, J BIOL CHEM, V251, P1104

[4] INVITRO BINDING OF TRIIODOTHYRONINE TO RAT-LIVER MITOCHONDRIA [J].

GOGLIA, F ;

TORRESANI, J ;

BUGLI, P ;

BARLETTA, A ;

LIVERINI, G .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 390 (02) :120-124

[5] THYROID-HORMONE UPTAKE INTO THE CELL AND ITS SUBSEQUENT LOCALIZATION TO THE MITOCHONDRIA [J].

HAFNER, RP .

FEBS LETTERS, 1987, 224 (02) :251-256

[6] LOCALIZATION OF 3,5,3'-L-TRIIODOTHYRONINE RECEPTOR IN RAT-KIDNEY MITOCHONDRIAL-MEMBRANES [J].

HASHIZUME, K ;

ICHIKAWA, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 106 (03) :920-926

[7] RAPID STIMULATION OF HEPATIC OXYGEN-CONSUMPTION BY 3,5-DI-IODO-L-THYRONINE [J].

HORST, C ;

ROKOS, H ;

SEITZ, HJ .

BIOCHEMICAL JOURNAL, 1989, 261 (03) :945-950

[8]

KADENBACH B, 1986, METHOD ENZYMOL, V126, P32

[9]

KAMINSKI T, 1980, Acta Endocrinologica Supplementum, V94, P15

[10] 3,5-T2 STIMULATES OXYGEN-CONSUMPTION, BUT NOT GLUCOSE-UPTAKE IN HUMAN MONONUCLEAR BLOOD-CELLS [J].

KVETNY, J .

HORMONE AND METABOLIC RESEARCH, 1992, 24 (07) :322-325

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