POTENT INHIBITORY EFFECT OF ANTIBIOTIC 1233A ON CHOLESTEROL-BIOSYNTHESIS WHICH SPECIFICALLY BLOCKS 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE

被引：64

作者：

OMURA, S

TOMODA, H

KUMAGAI, H

GREENSPAN, MD

YODKOVITZ, JB

CHEN, JS

ALBERTS, AW

MARTIN, I

MOCHALES, S

MONAGHAN, RL

CHABALA, JC

SCHWARTZ, RE

PATCHETT, AA

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

[2] MERCK SHARP & DOHME RES LABS,RAHWAY,NJ 07065

来源：

关键词：

D O I：

10.7164/antibiotics.40.1356

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：1356 / 1357

页数：2

共 7 条

[1] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT
ALBERTS, AW
CHEN, J
KURON, G
HUNT, V
HUFF, J
HOFFMAN, C
ROTHROCK, J
LOPEZ, M
JOSHUA, H
HARRIS, E
PATCHETT, A
MONAGHAN, R
CURRIE, S
STAPLEY, E
ALBERSSCHONBERG, G
HENSENS, O
HIRSHFIELD, J
HOOGSTEEN, K
LIESCH, J
SPRINGER, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07): : 3957 - 3961
[2] ANTIBIOTIC 1233A - FUNGAL BETA LACTONE
ALDRIDGE, DC
GILES, D
TURNER, WB
[J]. JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1971, (23): : 3888 - &
[3] CLINKENBEARD KD, 1975, J BIOL CHEM, V250, P3108
[4] CLINKENBEARD KD, 1973, J BIOL CHEM, V248, P2275
[5] COMPACTIN (ML-236B) AND RELATED-COMPOUNDS AS POTENTIAL CHOLESTEROL-LOWERING AGENTS THAT INHIBIT HMG-COA REDUCTASE
ENDO, A
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (04) : 401 - 405
[6] KURODA M, 1977, BIOCHIM BIOPHYS ACTA, V486, P70
[7] THIN-LAYER CHROMATOGRAPHIC ASSAY FOR HMG-COA REDUCTASE AND MEVALONIC ACID
SHAPIRO, DJ
IMBLUM, RL
RODWELL, VW
[J]. ANALYTICAL BIOCHEMISTRY, 1969, 31 (1-3) : 383 - &