REGULATION OF ISOTYPE SWITCHING

被引：54

作者：

VERCELLI, D ^{[1
]}

GEHA, RS ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 06期

关键词：

D O I：

10.1016/0952-7915(92)90064-L

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the past year, our understanding of the mechanisms that regulate isotype switching has significantly progressed. Activation of germ line transcription by isotype-specific cytokines is emerging as a crucial mechanism for increasing the accessibility of a particular switch region, and targeting switch recombination.

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页码：794 / 797

页数：4

相关论文

共 22 条

[1] MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A MURINE LIGAND FOR CD40 [J].

ARMITAGE, RJ ;

FANSLOW, WC ;

STROCKBINE, L ;

SATO, TA ;

CLIFFORD, KN ;

MACDUFF, BM ;

ANDERSON, DM ;

GIMPEL, SD ;

DAVISSMITH, T ;

MALISZEWSKI, CR ;

CLARK, EA ;

SMITH, CA ;

GRABSTEIN, KH ;

COSMAN, D ;

SPRIGGS, MK .

NATURE, 1992, 357 (6373) :80-82

[2]

Blackwell T. K., 1988, Molecular Immunology., P1

[3] INTERLEUKIN-10 AND TRANSFORMING GROWTH-FACTOR-BETA COOPERATE TO INDUCE ANTI-CD40 ACTIVATED NAIVE HUMAN B-CELLS TO SECRETE IMMUNOGLOBULIN-A [J].

DEFRANCE, T ;

VANBERVLIET, B ;

BRIERE, F ;

DURAND, I ;

ROUSSET, F ;

BANCHEREAU, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (03) :671-682

[4]

DERYCKX S, 1992, J IMMUNOL, V148, P1465

[5]

GAUCHAT JF, 1992, J IMMUNOL, V148, P2291

[6] STRUCTURE AND EXPRESSION OF GERMLINE EPSILON-TRANSCRIPTS IN HUMAN B-CELLS INDUCED BY INTERLEUKIN-4 TO SWITCH TO IGE PRODUCTION [J].

GAUCHAT, JF ;

LEBMAN, DA ;

COFFMAN, RL ;

GASCAN, H ;

DEVRIES, JE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (02) :463-473

[7]

JABARA HH, 1992, IN PRESS J IMMUNOL

[8]

LEBMAN DA, 1988, J IMMUNOL, V141, P2050

[9] MOLECULAR CHARACTERIZATION OF GERM-LINE IMMUNOGLOBULIN-A TRANSCRIPTS PRODUCED DURING TRANSFORMING GROWTH-FACTOR TYPE BETA-INDUCED ISOTYPE SWITCHING [J].

LEBMAN, DA ;

NOMURA, DY ;

COFFMAN, RL ;

LEE, FD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (10) :3962-3966

[10] IDENTIFICATION OF A NOVEL SURFACE PROTEIN ON ACTIVATED CD4+ T-CELLS THAT INDUCES CONTACT-DEPENDENT B-CELL DIFFERENTIATION (HELP) [J].

LEDERMAN, S ;

YELLIN, MJ ;

KRICHEVSKY, A ;

BELKO, J ;

LEE, JJ ;

CHESS, L .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (04) :1091-1101