MOLECULAR-BIOLOGY OF THE CALCIUM-ANTAGONIST RECEPTOR

被引：16

作者：

SLISH, DF ^{[1
]}

SCHULTZ, D ^{[1
]}

SCHWARTZ, A ^{[1
]}

机构：

[1] UNIV CINCINNATI, COLL MED, DEPT PHARMACOL & CELL BIOPHYS, 231 BETHESDA AVE, CINCINNATI, OH 45267 USA

来源：

HYPERTENSION | 1992年 / 19卷 / 01期

关键词：

ION CHANNELS; DIHYDROPYRIDINES; MOLECULAR BIOLOGY; CALCIUM CHANNEL BLOCKERS;

D O I：

10.1161/01.HYP.19.1.19

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The calcium channel plays a key role in controlling many physiological processes in the body. Drugs that block the calcium channel have proven clinically effective for the treatment of a multitude of cardiovascular disorders. The elucidation of the precise mechanism of action of these drugs involves cloning the calcium channels on which they act. Genetic manipulation of these cloned channels is beginning to reveal the binding sites for the calcium channel blocking drugs and may lead to the development of more specific agents.

引用

页码：19 / 24

页数：6

共 55 条

[1] LOW-VOLTAGE-ACTIVATED CALCIUM CURRENT IN RAT AORTA SMOOTH-MUSCLE CELLS IN PRIMARY CULTURE [J].