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NO-BULLET, CO AND BULLET-OH - ENDOGENOUS SOLUBLE GUANYLYL CYCLASE-ACTIVATING FACTORS

被引：185
作者：
SCHMIDT, HHHW [1 ]
机构：
[1] NORTHWESTERN UNIV, SCH MED, DEPT PHARMACOL, CHICAGO, IL 60611 USA
来源：
FEBS LETTERS | 1992年 / 307卷 / 01期
关键词：
L-ARGININE; HEME OXYGENASE; CARBON MONOXIDE; LIPID PEROXIDATION; XANTHINE OXIDASE; HYDROXYL RADICAL; CYCLIC GMP;
D O I：
10.1016/0014-5793(92)80910-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several low molecular weight compounds are capable of activating soluble guanylyl cyclase. Recent evidence suggests that some of these arc formed under physiological conditions: the nitric oxide radical, carbon monoxide and the hydroxyl radical. Thus, multiple signal transduction pathways appear to exist that form a family of guanylyl cyclase activating factors and thereby regulate the intracellular cyclic guanosine 3',5'-monophosphate level.
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页码：102 / 107
页数：6
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