NO-BULLET, CO AND BULLET-OH - ENDOGENOUS SOLUBLE GUANYLYL CYCLASE-ACTIVATING FACTORS

被引：185

作者：

SCHMIDT, HHHW ^{[1
]}

机构：

[1] NORTHWESTERN UNIV, SCH MED, DEPT PHARMACOL, CHICAGO, IL 60611 USA

来源：

FEBS LETTERS | 1992年 / 307卷 / 01期

关键词：

L-ARGININE; HEME OXYGENASE; CARBON MONOXIDE; LIPID PEROXIDATION; XANTHINE OXIDASE; HYDROXYL RADICAL; CYCLIC GMP;

D O I：

10.1016/0014-5793(92)80910-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several low molecular weight compounds are capable of activating soluble guanylyl cyclase. Recent evidence suggests that some of these arc formed under physiological conditions: the nitric oxide radical, carbon monoxide and the hydroxyl radical. Thus, multiple signal transduction pathways appear to exist that form a family of guanylyl cyclase activating factors and thereby regulate the intracellular cyclic guanosine 3',5'-monophosphate level.

引用

页码：102 / 107

页数：6

共 82 条

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