PREPARATION AND CHARACTERIZATION OF NIOSOMES CONTAINING RIFAMPICIN FOR LUNG TARGETING

被引：58

作者：

JAIN, CP ^{[1
]}

VYAS, SP ^{[1
]}

机构：

[1] DEPT PHARMACEUT SCI,PHARMACEUT RES LAB,SAGAR 470003,MADHYA PRADESH,INDIA

来源：

JOURNAL OF MICROENCAPSULATION | 1995年 / 12卷 / 04期

关键词：

NIOSOME; RIFAMPICIN LUNG; TARGETING; NONIONIC SURFACTANT; VESICLE;

D O I：

10.3109/02652049509087252

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Niosomes (non-ionic, surfactant-based vesicles) containing rifampicin of 8-15 mu m in diameter were prepared using Span-85 and cholesterol in various molar fractions. The process variables that could affect the physical characteristics of niosomes and in vitro release of the drug from the niosomes were studied and optimized. In vivo distribution studies of the prepared niosomes found that 65% of the drug could be localized in the lungs by controlling the niosome size.

引用

页码：401 / 407

页数：7

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