NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders

被引:208
作者
Krystal, JH
D'Souza, DC
Petrakis, IL
Belger, A
Berman, RM
Charney, DS
Abi-Saab, W
Madonick, S
机构
[1] Connecticut Mental Hlth Ctr, Abraham Ribicoff Res Facil, New Haven, CT 06519 USA
[2] Yale Univ, Sch Med, Dept Psychiat, Div Cognit & Clin Neurosci, New Haven, CT USA
[3] VA Connecticut Healthcare Syst, Psychiat Serv, West Haven, CT USA
关键词
D O I
10.1093/hrp/7.3.125
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Antagonists of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors and agonists of the glycine-B coagonist site of these receptors have been important tools for characterizing the contributions of NMDA receptor pathophysiology to a large number of neuropsychiatric conditions and for treating these conditions. Among these disorders are Alzheimer's disease, chronic pain syndromes, epilepsy, schizophrenia, Parkinson's disease, Huntington's disease, addiction disorders, major depression, and anxiety disorders. This review will examine pathophysiological and therapeutic hypotheses generated or supported by clinical studies employing NMDA antagonists and glycine-B agonists and partial agonists. It will also consider ethical issues related to human psychopharmacological studies employing glutamatergic probes.
引用
收藏
页码:125 / 143
页数:19
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