THE CD5(+) B-CELLS AND MYASTHENIA-GRAVIS

被引：6

作者：

ARAGA, S

KISHIMOTO, M

ADACHI, A

NAKAYASU, H

TAKENAKA, T

TAKAHASHI, K

机构：

[1] Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University

来源：

AUTOIMMUNITY | 1995年 / 20卷 / 02期

关键词：

THYMOCYTES; 2-COLOR ANALYSIS; FLOW CYTOMETRY; THYMECTOMY;

D O I：

10.3109/08916939509001937

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A high frequency of CD5(+)B lymphocytes in the peripheral blood of patients with myasthenia gravis (MG) has been reported recently. These results seem to indicate an attractive linkage between CD5(+)B lymphocytes and autoantibodies against Acetylcholine receptor in MG. We examined the frequency of CD5+B cells in 20 patients with MG and 21 normal healthy controls by two-color flow cytometry. However, there were no significant differences in the percentages of CD5(+)B lymphocytes between the two groups. We also examined the frequency of CD5(+)B lymphocytes in the resected thymus of patients. The frequency of CD5(+)B lymphocytes in the thymus was low and similar pattern to that in the peripheral blood. We checked the antibody (Ab) production against the human acetylcholine receptor in either CD5(+)B or CD5(-)B lymphoctes using B lymphoblastoid cell line generated from the lymphocytes of 11 patients with anti-AChR Abs in the sera. Abs against the AChR in the human were mostly produced by CD5(-)B, not CD5(+)B lymphocytes. The anti-AChR Abs (IgG) production of CD5(+)B cells and CD5(-)B cells (mean +/- SD) were 6.8 +/- 2.4 fmol/ml and 18.5 +/- 17.6 fmol/ml, respectively. These results sugget that in MG, the frequencies of the CD5(+)B lymphocytes in PBL may be genetic background and that there may be no strong linages between AChR Ab production and CD5(+)B lymphocytes.

引用

页码：129 / 134

页数：6

共 26 条

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