SENSITIZATION OF X-IRRADIATED CHINESE-HAMSTER V79-CELLS BY DERIVATIVES OF PYRIMIDINE NUCLEOSIDES

被引：7

作者：

HIRAOKA, W ^{[1
]}

TANABE, K ^{[1
]}

KUWABARA, M ^{[1
]}

SATO, F ^{[1
]}

MATSUDA, A ^{[1
]}

UEDA, T ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,SAPPORO,HOKKAIDO 060,JAPAN

来源：

JOURNAL OF RADIATION RESEARCH | 1988年 / 29卷 / 04期

关键词：

Aromatic compounds - Biomolecules - Cytology - Ionizing radiation - Irradiation - Mammals - Radiation effects - Viruses;

D O I：

10.1269/jrr.29.246

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The modification of the lethal effects of ionizing radiation on cultured mammalian cells by the pyrimidine nucleoside analogues, 3'-azido-2',3'-dideoxythymidine, 3'-amino-2',3'-dideoxythymidine, 2',3'-didehydro-2',3'- dideoxythymidine and 2',3'-didehydro-2',3'-dideoxycytidine, was investigated using X-irradiated log-phase Chinese hamster V79 cells. The exposure of the cells to these drugs (1-7.5 mM) for 3h after X irradiation reduced the cell survival. The killing efficiency was further enhanced by treating the cells with the drugs for 3h before X irradiation and continuing the treatment for 3h after X irradiation. These observations reveal that the nucleoside analogues, which are known as inhibitors of human immunodeficiency virus replication, have the ability to suppress cellular recovery from the radiation-induced potentially lethal state of X-irradiated cells. © 1988 Oxford University Press. All rights reserved.

引用

页码：246 / 254

页数：9

共 16 条

[1] BOTH 2',3'-DIDEOXYTHYMIDINE AND ITS 2',3'-UNSATURATED DERIVATIVE (2',3'-DI-DEOXYTHYMIDINENE) ARE POTENT AND SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-REPLICATION INVITRO [J].

BABA, M ;

PAUWELS, R ;

HERDEWIJN, P ;

DECLERCQ, E ;

DESMYTER, J ;

VANDEPUTTE, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (01) :128-134

[2] POTENT AND SELECTIVE ANTI-HTLV-III/LAV ACTIVITY OF 2',3'-DIDEOXYCYTIDINENE, THE 2',3'-UNSATURATED DERIVATIVE OF 2',3'-DIDEOXYCYTIDINE [J].

BALZARINI, J ;

PAUWELS, R ;

HERDEWIJN, P ;

DECLERCQ, E ;

COONEY, DA ;

KANG, GJ ;

DALAL, M ;

JOHNS, DG ;

BRODER, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 140 (02) :735-742

[3]

Fricke H., 1966, RAD DOSIMETRY INSTRU, P167

[4] PHOSPHORYLATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE AND SELECTIVE INTERACTION OF THE 5'-TRIPHOSPHATE WITH HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE [J].

FURMAN, PA ;

FYFE, JA ;

STCLAIR, MH ;

WEINHOLD, K ;

RIDEOUT, JL ;

FREEMAN, GA ;

LEHRMAN, SN ;

BOLOGNESI, DP ;

BRODER, S ;

MITSUYA, H ;

BARRY, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) :8333-8337

[5] INHIBITORY EFFECT OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES ON INFECTIVITY, CYTOPATHIC EFFECTS, AND REPLICATION OF HUMAN-IMMUNODEFICIENCY-VIRUS [J].

HAMAMOTO, Y ;

NAKASHIMA, H ;

MATSUI, T ;

MATSUDA, A ;

UEDA, T ;

YAMAMOTO, N .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (06) :907-910

[6]

HORWITZ J. P., 1966, TETRAHEDRON LETT, V13, P1343

[7] NUCLEOSIDES .5. MONOMESYLATES OF 1-(2]-DEOXY-BETA-D-LYXOFURANOSYL)THYMINE [J].

HORWITZ, JP ;

CHUA, J ;

NOEL, M .

JOURNAL OF ORGANIC CHEMISTRY, 1964, 29 (07) :2076-&

[8] NUCLEOSIDES .11. 2',3'-DIDEOXYCYTIDIN [J].

HORWITZ, JP ;

CHUA, J ;

NOEL, M ;

DONATTI, JT .

JOURNAL OF ORGANIC CHEMISTRY, 1967, 32 (03) :817-&

[9] QUANTITATIVE ASPECTS OF REPAIR OF POTENTIALLY LETHAL DAMAGE IN MAMMALIAN-CELLS [J].

ILIAKIS, G ;

POHLIT, W .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1979, 36 (06) :649-658

[10] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SEVERAL AMINO ANALOGS OF THYMIDINE [J].

LIN, TS ;

PRUSOFF, WH .

JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (01) :109-112

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