EFFECT OF NORMOBARIC OXYGEN ON TUMOR RADIOSENSITIVITY - FRACTIONATED STUDIES

被引：33

作者：

ROJAS, A

CARL, U

REGHEBI, K

机构：

[1] CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1990年 / 18卷 / 03期

关键词：

Carbogen; Fractionation; Hypoxia; Oxygen; Radiosensitizers; Tumors;

D O I：

10.1016/0360-3016(90)90059-S

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The sensitizing ability of 100% normobaric oxygen was investigated in a mouse mammary carcinoma (CaNT) using a variety of fractionated regimens. Both regrowth delay and local control were used as assays of tumor response. With both assays, there was a similar and significant increase in radiosensitivity for all fractionated schedules. Enhancement ratios ranged from 1.24 to 1.45, the highest increase being observed with a 30 fraction schedule given in an overall time of 6 weeks. Thus, in CaNT tumors normobaric oxygen is a far more efficient radiosensitizer in fractionated treatments than the oxygen-mimetic compound misonidazole; an oxygen effect being observed at doses per fraction as low as 1.8 Gy. These results suggest strongly that normobaric gases could play an important role in the clinical management of tumors where hypoxia may limit the outcome of radiotherapy. © 1990.

引用

页码：547 / 553

页数：7

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