BLOOD RHEOLOGY AND CARDIOVASCULAR RISK-FACTORS IN TYPE-1 DIABETES - RELATIONSHIP WITH MICROALBUMINURIA

被引：35

作者：

JAY, RH

JONES, SL

HILL, CE

RICHMOND, W

VIBERTI, GC

RAMPLING, MW

BETTERIDGE, DJ

机构：

[1] Department of Medicine, University College and Middlesex School of Medicine, The Rayne Institute

[2] Unit for Metabolic Medicine, United Medical and Dental Schools, Guy's Hospital

[3] Department of Physiology and Biophysics, St. Mary's Hospital Medical School, London

来源：

DIABETIC MEDICINE | 1991年 / 8卷 / 07期

关键词：

TYPE-1; DIABETES-MELLITUS; MICROALBUMINURIA; BLOOD RHEOLOGY; FIBRINOGEN; LIPIDS; LIPOPROTEINS; LIPOPROTEIN(A);

D O I：

10.1111/j.1464-5491.1991.tb01674.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Whole blood and plasma viscosity, erythrocyte aggregation and deformability, plasma fibrinogen, lipids, lipoproteins, apolipoproteins, and measures of blood glucose control were compared between 21 Type 1 diabetic patients with microalbuminuria (overnight albumin excretion rate 30-200-mu-g min-1) and 21 patients with albumin excretion below this range matched for age, sex, and duration of diabetes. Patients with microalbuminuria had significantly higher glycosylated haemoglobin (9.4 +/- 1.6 (+/- SD) vs 7.9 +/- 1.8 % (normal range 5.0 to 7.6 %)), total-cholesterol (5.6 +/- 1.1 vs 4.6 +/- 1.3 mmol l-1), apolipoprotein B (0.82 +/- 0.21 vs 0.66 +/- 0.14 g l-1), and apolipoprotein B:A1 ratio (0.58 +/- 0.18 vs 0.50 +/- 0.15) than those without microalbuminuria (all p < 0.05). HDL-cholesterol was also raised (1.71 +/- 0.46 vs 1.43 +/- 0.37 mmol l-1, p < 0.05). Lipoprotein(a) concentration was possibly higher in the microalbuminuric group (median (95 % Cl) 105 (82-140) vs 72 (52-114) mg l-1, p = 0.06). No differences were seen in any of the rheological measurements. These results confirm the presence of potentially atherogenic lipoprotein changes in Type 1 diabetic patients with microalbuminuria, but suggest that altered blood rheology does not predate the development of nephropathy.

引用

页码：662 / 667

页数：6

共 43 条

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