A REDUCTIVE ALDOL STRATEGY FOR THE SYNTHESIS OF VERY HIGHLY SUBSTITUTED CYCLOPENTANES FROM SUGAR LACTONES

被引：15

作者：

ELLIOTT, RP

FLEET, GWJ

PEARCE, L

SMITH, C

WATKIN, DJ

机构：

[1] UNIV OXFORD,DYSON PERRINS LAB,S PARKS RD,OXFORD OX1 3QY,ENGLAND

[2] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

[3] UNIV OXFORD,CRYSTALLOG LAB,OXFORD OX1 3PD,ENGLAND

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 43期

关键词：

D O I：

10.1016/0040-4039(91)80795-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iodide ion induces a protected 5-formyl-2-iodo-1,5-lactone to undergo a reductive aldol condensation to give a fully substituted cyclopentane derivative in moderate yield; this strategy may provide a general synthesis of such highly functionalised carbocycles as mannostatins and allosamizolines.

引用

页码：6227 / 6230

页数：4

共 21 条

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