A REDUCTIVE ALDOL STRATEGY FOR THE SYNTHESIS OF VERY HIGHLY SUBSTITUTED CYCLOPENTANES FROM SUGAR LACTONES

被引:15
作者
ELLIOTT, RP
FLEET, GWJ
PEARCE, L
SMITH, C
WATKIN, DJ
机构
[1] UNIV OXFORD,DYSON PERRINS LAB,S PARKS RD,OXFORD OX1 3QY,ENGLAND
[2] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND
[3] UNIV OXFORD,CRYSTALLOG LAB,OXFORD OX1 3PD,ENGLAND
关键词
D O I
10.1016/0040-4039(91)80795-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Iodide ion induces a protected 5-formyl-2-iodo-1,5-lactone to undergo a reductive aldol condensation to give a fully substituted cyclopentane derivative in moderate yield; this strategy may provide a general synthesis of such highly functionalised carbocycles as mannostatins and allosamizolines.
引用
收藏
页码:6227 / 6230
页数:4
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