SYNTHESIS FROM A HEPTONOLACTONE AND EFFECT ON GLYCOSIDASES OF (1S,2R,6R,7S)-1,2,6,7-TETRAHYDROXYPYRROLIZIDINE

被引：29

作者：

FAIRBANKS, AJ

FLEET, GWJ

JONES, AH

BRUCE, I

ALDAHER, S

DIBELLO, IC

WINCHESTER, B

机构：

[1] DYSON PERRINS LAB,S PARKS RD,OXFORD OX1 3QY,ENGLAND

[2] INST CHILD HLTH,DEPT CLIN BIOCHEM,LONDON WC1N 1EH,ENGLAND

[3] OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON | 1991年 / 47卷 / 01期

关键词：

D O I：

10.1016/0040-4020(91)80015-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A five step synthesis of the pseudo C2 symmetric (1S,2R,6R,7S)-1,2,6,7-tetrahydroxypyrrolizidine from 2,3:5,6-di-O-isopropylidene-D-glycero-D-talo-heptono-1,4-lactone is reported. The effects of structure of some polyhydroxylated pyrrolizidines and pyrrolidines on inhibition of mannosidases are compared. © 1991.

引用

页码：131 / 138

页数：8

共 20 条

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