EFFECT ON HUMAN LIVER GLYCOSIDASES AND SHORT SYNTHESES OF 1-ALPHA,2-ALPHA,6-ALPHA,7-ALPHA,7A-BETA-1,2,6,7-TETRAHYDROXYPYRROLIZIDINE FROM D-GLYCERO-D-GULO-HEPTONO-1,4-LACTONE

被引:14
作者
COLLIN, WF
FLEET, GWJ
HARALDSSON, M
DIBELLO, IC
WINCHESTER, B
机构
[1] UNIV OXFORD,OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND
[2] UNIV LONDON,INST CHILD HLTH,DEPT CLIN BIOCHEM,LONDON WC1N 1EH,ENGLAND
关键词
D O I
10.1016/0008-6215(90)84074-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The synthesis of 1a,2a,6a,7a,7aβ-1,2,6,7-tetrahydroxypyrrolizidine (1) from d-glycero-d-gulo-heptono-1,4-lactone (6) by two different routes is reported. The effects of 1 on the inhibition of 15 human liver glycosidases are described. © 1990.
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页码:105 / 116
页数:12
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