SYNAPSIS AND OBLIGATE RECOMBINATION BETWEEN THE SEX-CHROMOSOMES OF MALE LABORATORY MICE CARRYING THE Y-STAR REARRANGEMENT

被引:28
作者
HALE, DW [1 ]
HUNT, PA [1 ]
TUCKER, PK [1 ]
EICHER, EM [1 ]
机构
[1] JACKSON LAB,BAR HARBOR,ME 04609
来源
CYTOGENETICS AND CELL GENETICS | 1991年 / 57卷 / 04期
关键词
D O I
10.1159/000133153
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The synaptic and recombinational behavior of the sex chromosomes in male laboratory mice carrying the Y* rearrangement was analyzed by light and electron microscopy. Examination of zygotene and pachytene X-Y* configurations revealed a surprising paucity of the staggered pairing configuration predicted from the distal position of the X pseudoautosomal region and the subcentromeric position of the Y* pseudoautosomal region. When paired at pachynema, the X and Y* chromosomes usually assumed configurations similar to those of typical sex bivalents from normal male laboratory mice. The X and Y* chromosomes were present as univalents in more than half of the early- and mid-pachytene nuclei, presumably as a result of steric difficulties associated with homologous alignment of the pseudoautosomal regions. When paired at diakinesis and meta-phase I, the X and Y* chromosomes exhibited an asymmetrical chiasmatic association indicative of recombination within the staggered synaptic configuration. Both pairing disruption and recombinational failure apparently contribute to diakinesis/metaphase I sex-chromosome univalency, as most cells at these stages possessed X and Y* univalents lacking evidence of prior recombination. Recombinant X or Y* chromosomes were detected in all metaphase II complements examined, thus substantiating the hypothesis that X-Y recombination is a prerequisite for the normal progression of male meiosis.
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页码:231 / 239
页数:9
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