OPTIMIZATION OF THE HEWLETT-PACKARD PARTICLE-BEAM LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY INTERFACE BY STATISTICAL EXPERIMENTAL-DESIGN

被引：7

作者：

HUANG, SK

GARZA, NR

机构：

[1] Hoechst Celanese Corporation, Corpus Christi, Texas

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 1995年 / 6卷 / 06期

关键词：

D O I：

10.1016/1044-0305(95)00055-I

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Optimization of both sensitivity and ionization softness for the Hewlett-Packard particle-beam liquid chromatography-mass spectrometry interface has been achieved by using a statistical experimental design with response surface modeling. Conditions for both optimized sensitivity and ionization softness were found to occur at 55-lb/in.(2) nebulizer flow, 35 degrees C desolvation chamber temperature with approximately 45% organic modifier in the presence of 0.02-F ammonium acetate and a liquid chromatography flow rate of 0.2 mL/min.

引用

页码：507 / 512

页数：6

共 12 条

[1] LIQUID-CHROMATOGRAPHY PARTICLE BEAM MASS-SPECTROMETRY OF POLAR COMPOUNDS OF ENVIRONMENTAL INTEREST [J].