SYNTHESIS AND INFLUENCE OF THE STEREOCHEMISTRY ON ANTICONVULSANT ACTIVITY OF 1-AZA[3.3.0]BICYCLO-OCTANES

被引:8
作者
DIAFI, L
RUBAT, C
COUDERT, P
BASTIDE, P
MARGOUM, N
TRONCHE, P
机构
[1] FAC PHARM CLERMONT FERAND,CHIM THERAPEUT LAB,28 PL HENRI DUNANT,F-63001 CLERMONT FERRAND,FRANCE
[2] FAC PHARM CLERMONT FERRAND,PHARMACOL & PHARM CLIN LAB,RECH PHARMACOL GRP,F-63001 CLERMONT FERRAND,FRANCE
关键词
1-AZA[3.3.0]BICYCLOOCTANES; PHOTOCHEMISTRY; ANTICONVULSANT; MOTILITY; GRAPHIC MODELING;
D O I
10.1016/0223-5234(91)90034-K
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
New diastereo-isomeric 1-aza[3.3.0]bicyclo octanes have been prepared by a photochemistry process. They have been separated by chromatography and identified by 300 MHz 1H-NMR study. Trans derivative has shown more marked anticonvulsant effects than cis isomere did. Graphic modelling revealed the importance of the aromatic ring position in relation to bicyclic system for activity.
引用
收藏
页码:231 / 235
页数:5
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