OXIDATIVE DAMAGE TO LIPIDS AND ALPHA(1)-ANTIPROTEINASE BY PHENYLBUTAZONE IN THE PRESENCE OF HEME-PROTEINS - PROTECTION BY ASCORBIC-ACID

被引：33

作者：

EVANS, PJ ^{[1
]}

CECCHINI, R ^{[1
]}

HALLIWELL, B ^{[1
]}

机构：

[1] UNIV CALIF DAVIS, SACRAMENTO MED CTR, MED CTR, DIV PULM CRIT CARE MED, SACRAMENTO, CA 95817 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 05期

关键词：

D O I：

10.1016/0006-2952(92)90131-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Phenylbutazone is an anti-inflammatory drug with numerous side-effects that restrict its clinical use. In the presence of myoglobin, or of haemoglobin plus H2O2, phenylbutazone accelerates the peroxidation of lipids (arachidonic acid and rat liver microsomes) and cause's the inactivation of alpha-antiproteinase, so that this protein can no longer inhibit elastase. We propose that haem proteins oxidize phenylbutazone into a damaging free radical. Ascorbic acid inhibits these pro-oxidant actions of phenylbutazone.

引用

页码：981 / 984

页数：4

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