GENERALIZATION OF MONOD KINETICS FOR ANALYSIS OF GROWTH DATA WITH SUBSTRATE-INHIBITION

The inhibitory effect of butanol on yeast growth has been studied for the strain Candida utilis ATCC 8205 growing aerobically on butanol under batch conditions. A mathematic expression was then proposed to fit the kinetic pattern of butanol inhibition on the specific growth rate: .**GRAPHIC**. The maximum allowable butanol concentration above which cells do not grow was predicted to be 9.16 g/L. The proposed model appears to accurately represent the experimental data obtained in this study and the literature data developed for a variety of batch culture systems at widely ranging substrate concentrations.