CURRENT STATUS OF ANTIOXIDANT THERAPY

被引:368
作者
RICEEVANS, CA
DIPLOCK, AT
机构
[1] Free Radical Research Group, Division of Biochemistry, Guy's Hospital, London, SE1 9RT, United Medical and Dental Schools Guy's and St. Thomas's Hospitals
关键词
FREE RADICAL; ANTIOXIDANT; ALPHA-TOCOPHEROL; THIOL DRUGS; HYDROXAMATES; DESFERRIOXAMINE; ATHEROSCLEROSIS; REPERFUSION INJURY; OXIDIZED LDL;
D O I
10.1016/0891-5849(93)90127-G
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There is evidence that free radical damage contributes to the aetiology of many chronic health problems such as emphysema, cardiovascular and inflammatory diseases, cataracts, and cancer. In this review we are not concerned with tissue damage in vivo induced directly by radicals from exogenous sources, such as air pollutants and tobacco smoke, high-pressure oxygen, irradiation, or through the metabolism of certain solvents, drugs, and pesticides. Rather, we address some of the disease states associated with increased oxidative stress from endogenous sources and the possible therapeutic advantage of the antioxidant treatment. This raises the question of the antioxidant status of individuals and its role in protection against amplification of certain disease processes. We have chosen to concentrate mainly on coronary heart disease, reperfusion injury, and organ storage for transplantation.
引用
收藏
页码:77 / 96
页数:20
相关论文
共 160 条