PREVENTION OF VERTEBRATE NEURONAL DEATH BY THE CRMA GENE

被引：625

作者：

GAGLIARDINI, V

FERNANDEZ, PA

LEE, RKK

DREXLER, HCA

ROTELLO, RJ

FISHMAN, MC

YUAN, J

机构：

[1] MASSACHUSETTS GEN HOSP, CARDIOVASC RES CTR, 149 13TH ST, BOSTON, MA 02129 USA

[2] HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA

来源：

SCIENCE | 1994年 / 263卷 / 5148期

关键词：

D O I：

10.1126/science.8303301

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interleukin-1beta converting enzyme (ICE) is a mammalian homolog of CED-3, a protein required for programmed cell death in the nematode Caenorhabditis elegans. The activity of ICE can be specifically inhibited by the product of crmA, a cytokine response modifier gene encoded by cowpox virus. Microinjection of the crmA gene into chicken dorsal root ganglion neurons was found to prevent cell death induced by deprivation of nerve growth factor. Thus, ICE is likely to participate in neuronal death in vertebrates.

引用

页码：826 / 828

页数：3

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