CHROMATOGRAPHIC ANALYSIS OF SELECTED TETRACYCLINES FROM DOSAGE FORMS AND BULK DRUG SUBSTANCE USING POLYMERIC COLUMNS WITH ACIDIC MOBILE PHASES

被引：30

作者：

BRYAN, PD ^{[1
]}

STEWART, JT ^{[1
]}

机构：

[1] UNIV GEORGIA, COLL PHARM, DEPT MED CHEM, ATHENS, GA 30602 USA

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1994年 / 12卷 / 05期

关键词：

LC; PHARMACEUTICAL ANALYSIS; POLYMERIC COLUMNS; MINOCYCLINE; OXYTETRACYCLINE; TETRACYCLINE; DEMECLOCYCLINE; CHLORTETRACYCLINE; METHACYCLINE; DOXYCYCLINE; MECLOCYCLINE;

D O I：

10.1016/0731-7085(93)E0013-D

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The LC analysis of selected tetracyclines from dosage forms and bulk drug substance using polymeric columns has been studied. Mobile phases containing acetonitrile-0.02 M sodium perchlorate (pH 2.0) were used. The tetracyclines were detected by their absorbance at 280 nm. The columns included: a polystyrene-divinylbenzene (PS-DVB) column and a polymethacrylate column with octadecyl ligands (PM-C18). Performance of the two columns was compared and applicability of the described methods for compendial use has been evaluated. The tetracyclines investigated include: minocycline, oxytetracycline, tetracycline, demeclocycline, chlortetracycline, methacycline, doxycycline and meclocycline.

引用

页码：675 / 692

页数：18