DISTRIBUTION OF NADPH-DIAPHORASE-POSITIVE NERVES SUPPLYING THE HUMAN URINARY-BLADDER

被引:40
作者
SMET, PJ
EDYVANE, KA
JONAVICIUS, J
MARSHALL, VR
机构
[1] Division of Surgery, Repatriation General Hospital, Adelaide, SA 5041, Daws Road, Daw Park
来源
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 1994年 / 47卷 / 1-2期
基金
英国医学研究理事会;
关键词
URINARY BLADDER; HUMAN; NADPH DIAPHORASE; NITRIC OXIDE SYNTHASE; INNERVATION;
D O I
10.1016/0165-1838(94)90071-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd) histochemistry was used as a marker for neuronal nitric oxide synthase in human bladder tissue. A plexus of NADPHd-containing nerve fibres was observed in bladder biopsies taken from both the lateral wall and trigone regions. Varicose terminals were present in smooth muscle bundles of the detrusor and trigone, and more commonly within the submucosal layer. Reactive fibres were seen running immediately beneath and along the urothelium, and additional nerves formed perivascular plexi around some blood vessels. Fewer positive nerve processes were observed in the trigone region in comparison to the bladder wall. NADPHd-reactive neuronal perikarya were present within intramural ganglia, some of which were in close proximity to NADPHd-stained varicosities. The results indicate that nitric oxide may be involved in the regulation of bladder function in humans.
引用
收藏
页码:109 / 113
页数:5
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