INHIBITION OF BOVINE MONONUCLEAR CELL-PROLIFERATION, INTERLEUKIN-2 SYNTHESIS, PROTEIN-TYROSINE KINASE AND LEUKOTRIENE-B(4) PRODUCTION BY A PROTEIN-TYROSINE KINASE INHIBITOR, GENISTEIN

被引：11

作者：

ATLURU, D

GUDAPATY, S

机构：

[1] Department of Medicine/Nephrology, Hennepin County Medical Center, RKDP, Minneapolis, MN 555404, 914 South 8th Street

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1993年 / 38卷 / 1-2期

关键词：

D O I：

10.1016/0165-2427(93)90117-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genistein, an isoflavanoid compound, a selective inhibitor of protein-tyrosine kinase (PTK), inhibited PHA-stimulated bovine peripheral blood mononuclear cell proliferation (PBMC), interleukin-2 (IL-2) production, phosphorylation of PTK p56lck. Further, genistein also inhibited leukotriene B4 production from A-23187 stimulated cultures. Our data suggest that the PTK plays an important role in the signal transduction of bovine PBMC proliferation.

引用

页码：113 / 122

页数：10

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