INHIBITION OF BOVINE MONONUCLEAR CELL-PROLIFERATION, INTERLEUKIN-2 SYNTHESIS, PROTEIN-TYROSINE KINASE AND LEUKOTRIENE-B(4) PRODUCTION BY A PROTEIN-TYROSINE KINASE INHIBITOR, GENISTEIN

被引：11

作者：

ATLURU, D

GUDAPATY, S

机构：

[1] Department of Medicine/Nephrology, Hennepin County Medical Center, RKDP, Minneapolis, MN 555404, 914 South 8th Street

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1993年 / 38卷 / 1-2期

关键词：

D O I：

10.1016/0165-2427(93)90117-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genistein, an isoflavanoid compound, a selective inhibitor of protein-tyrosine kinase (PTK), inhibited PHA-stimulated bovine peripheral blood mononuclear cell proliferation (PBMC), interleukin-2 (IL-2) production, phosphorylation of PTK p56lck. Further, genistein also inhibited leukotriene B4 production from A-23187 stimulated cultures. Our data suggest that the PTK plays an important role in the signal transduction of bovine PBMC proliferation.

引用

页码：113 / 122

页数：10

共 30 条

[11]

GOLDYNE ME, 1984, J BIOL CHEM, V259, P8815

[12] TYROSINE PROTEIN-KINASES, VIRAL TRANSFORMATION AND THE CONTROL OF CELL-PROLIFERATION [J].

HUNTER, T ;

GOULD, KL ;

COOPER, JA .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1984, 12 (05) :757-759

[13]

KLAUSNER RD, 1987, J BIOL CHEM, V262, P12654

[14]

LANE PJL, 1990, J IMMUNOL, V144, P3684

[15]

MARTH JD, 1986, P NATL ACD SCI US, V83, P7100

[16]

MCCOLL SR, 1991, BLOOD, V78, P1842

[17]

MILLS GB, 1990, J BIOL CHEM, V265, P3561

[18] T-CELL ANTIGEN RECEPTOR MEDIATED ACTIVATION OF PHOSPHOLIPASE-C REQUIRES TYROSINE PHOSPHORYLATION [J].

MUSTELIN, T ;

COGGESHALL, KM ;

ISAKOV, N ;

ALTMAN, A .

SCIENCE, 1990, 247 (4950) :1584-1587

[19] HIGHER TYROSINE PROTEIN-KINASE ACTIVITY IN RESTING LYMPHOCYTES THAN IN PROLIFERATING NORMAL OR LEUKEMIC BLOOD-CELLS [J].

PIGA, A ;

TAHERI, MR ;

YAXLEY, JC ;

WICKREMASINGHE, RG ;

HOFFBRAND, AV .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 124 (03) :766-773

[20] LEUKOTRIENE B4 UP-REGULATES IL-6 RATHER THAN IL-1 SYNTHESIS IN HUMAN MONOCYTES [J].

POUBELLE, PE ;

STANKOVA, J ;

GRASSI, J ;

ROLAPLESZCZYNSKI, M .

AGENTS AND ACTIONS, 1991, 34 (1-2) :42-45

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