IMPACT OF DOSING SCHEDULE UPON SUPPRESSION OF A RETROVIRUS IN A MURINE MODEL OF AIDS ENCEPHALOPATHY

被引：7

作者：

BILELLO, JA

EISEMAN, JL

STANDIFORD, HC

DRUSANO, GL

机构：

[1] UNIV MARYLAND, SCH MED, DEPT MED, DEPT MICROBIOL & IMMUNOL, BALTIMORE, MD 21201 USA

[2] UNIV MARYLAND, SCH MED, DEPT MED, CTR CANC, BALTIMORE, MD 21201 USA

[3] BALTIMORE VA MED CTR, BALTIMORE, MD 21201 USA

[4] UNIV MARYLAND, SCH MED, DEPT MED, BALTIMORE, MD 21201 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 03期

关键词：

D O I：

10.1128/AAC.38.3.628

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We studied the impact of zidovudine (AZT) in Cas-Br-M murine leukemia virus-infected NFS-N mice after administration by once-daily bolus or continuous infusion. While higher peak concentrations of AZT were achieved by once-daily dosing, continuous AZT infusion at 25 mu g/h maintained levels >1 mu M in plasma and >0.2 mu M in the brain. Continuous infusion provided significantly better viral inhibition, even though total doses were only one-third that of the once-daily therapy group.

引用

页码：628 / 631

页数：4

共 18 条

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