CELLULAR PHARMACOLOGY OF 2',3'-DIDEOXY-2',3'-DIDEHYDROTHYMIDINE, A NUCLEOSIDE ANALOG ACTIVE AGAINST HUMAN IMMUNODEFICIENCY VIRUS

被引:181
作者
HO, HT [1 ]
HITCHCOCK, MJM [1 ]
机构
[1] BRISTOL MYERS CO,DIV PHARMACEUT RES & DEV,POB 5100,5 RES PKWY,WALLINGFORD,CT 06492
关键词
D O I
10.1128/AAC.33.6.844
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
引用
收藏
页码:844 / 849
页数:6
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  • [1] INITIAL STUDIES ON THE CELLULAR PHARMACOLOGY OF 3'-DEOXYTHYMIDIN-2'-ENE (D4T) - A POTENT AND SELECTIVE INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS
    AUGUST, EM
    MARONGIU, ME
    LIN, TS
    PRUSOFF, WH
    [J]. BIOCHEMICAL PHARMACOLOGY, 1988, 37 (23) : 4419 - 4422
  • [2] BOTH 2',3'-DIDEOXYTHYMIDINE AND ITS 2',3'-UNSATURATED DERIVATIVE (2',3'-DI-DEOXYTHYMIDINENE) ARE POTENT AND SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-REPLICATION INVITRO
    BABA, M
    PAUWELS, R
    HERDEWIJN, P
    DECLERCQ, E
    DESMYTER, J
    VANDEPUTTE, M
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (01) : 128 - 134
  • [3] THE INVITRO AND INVIVO ANTI-RETROVIRUS ACTIVITY, AND INTRACELLULAR METABOLISM OF 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE AND 2',3'-DIDEOXYCYTIDINE ARE HIGHLY DEPENDENT ON THE CELL SPECIES
    BALZARINI, J
    PAUWELS, R
    BABA, M
    HERDEWIJN, P
    DECLERCQ, E
    BRODER, S
    JOHNS, DG
    [J]. BIOCHEMICAL PHARMACOLOGY, 1988, 37 (05) : 897 - 903
  • [4] BALZARINI J, 1987, MOL PHARMACOL, V32, P162
  • [5] ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS)
    BARRESINOUSSI, F
    CHERMANN, JC
    REY, F
    NUGEYRE, MT
    CHAMARET, S
    GRUEST, J
    DAUGUET, C
    AXLERBLIN, C
    VEZINETBRUN, F
    ROUZIOUX, C
    ROZENBAUM, W
    MONTAGNIER, L
    [J]. SCIENCE, 1983, 220 (4599) : 868 - 871
  • [6] KINETIC AND PHOTOCHEMICAL STUDIES AND ALTERATION OF UV SENSITIVITY OF ESCHERICHIA-COLI THYMIDINE KINASE BY HALOGENATED ALLOSTERIC REGULATORS AND SUBSTRATE ANALOGS
    CHEN, MS
    PRUSOFF, WH
    [J]. BIOCHEMISTRY, 1977, 16 (15) : 3310 - 3315
  • [7] CHEN MS, 1978, J BIOL CHEM, V253, P1325
  • [8] PROPERTIES OF 2',3'-DIDEOXY-2',3'-DEHYDROTHYMIDINE 5'-TRIPHOSPHATE IN TERMINATING DNA-SYNTHESIS CATALYZED BY SEVERAL DIFFERENT DNA-POLYMERASES
    DYATKINA, N
    MINASSIAN, S
    KUKHANOVA, M
    KRAYEVSKY, A
    VONJANTALIPINSKY, M
    CHIDGEAVADZE, Z
    BEABEALASHVILLI, R
    [J]. FEBS LETTERS, 1987, 219 (01) : 151 - 155
  • [9] THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
    FISCHL, MA
    RICHMAN, DD
    GRIECO, MH
    GOTTLIEB, MS
    VOLBERDING, PA
    LASKIN, OL
    LEEDOM, JM
    GROOPMAN, JE
    MILDVAN, D
    SCHOOLEY, RT
    JACKSON, GG
    DURACK, DT
    KING, D
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) : 185 - 191
  • [10] EFFECTS OF 3'-AZIDO-3'-DEOXYTHYMIDINE ON THE DEOXYNUCLEOTIDE TRIPHOSPHATE POOLS OF CULTURED HUMAN-CELLS
    FRICK, LW
    NELSON, DJ
    STCLAIR, MH
    FURMAN, PA
    KRENITSKY, TA
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (01) : 124 - 129