GENOTOXIC EFFECTS OF THE CARBAMATE INSECTICIDE, METHOMYL .2. IN-VIVO STUDIES WITH PURE COMPOUND AND THE TECHNICAL FORMULATION, LANNATE-25

被引：27

作者：

BOLOGNESI, C

PELUSO, M

DEGAN, P

RABBONI, R

MUNNIA, A

ABBONDANDOLO, A

机构：

[1] Centro Nazionale Per Lo Studio Dei Tumori di Origine Ambientale, Istituto Nazionale Per la Ricerca Sul Cancro, Genova

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1994年 / 24卷 / 03期

关键词：

PESTICIDES; IN VIVO GENOTOXICITY; MICRONUCLEUS TEST; ALKALINE ELUTION; P-32; POSTLABELING; DNA OXIDATIVE DAMAGE;

D O I：

10.1002/em.2850240313

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The carbamate insecticide, methomyl, and the methomyl-containing technical formulation, ''Lannate 25'', were tested for the induction of DNA damage in vivo. Swiss CD1 mice were treated intraperitoneally with test substances and the following tests were performed: alkaline elution of liver and kidney DNA, 8-hydroxy-guanosine detection in liver DNA, and P-32-postlabelling analysis of DNA adducts in liver DNA. The clastogenic activity of the two pesticide preparations was also evaluated as micro-nucleus frequency in bone marrow. No DNA adducts were detected in liver DNA of mice treated with pure methomyl, while a dose-related increase in DNA adducts was found in Lannate 25-treated animals. All other tests were positive with both methomyl and Lannate 25. A summary of genotoxic activity of methomyl is also presented. The hypothesis that the observed genotoxic effects of methomyl are induced indirectly, through formation of active oxygen species, is discussed. (C) 1994 Wiley-Liss, Inc.

引用

页码：235 / 242

页数：8

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