SOLID-PHASE SYNTHESIS OF 1,2,3,4-TETRAHYDRO-BETA-CARBOLINES - IMPLICATIONS FOR COMBINATORIAL CHEMISTRY

被引：58

作者：

KALJUSTE, K ^{[1
]}

UNDEN, A ^{[1
]}

机构：

[1] UNIV STOCKHOLM,DEPT NEUROCHEM & NEUROTOXICOL,S-10691 STOCKHOLM,SWEDEN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 50期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1016/0040-4039(95)01943-C

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general method for the solid phase synthesis of tetrahydro-P-carbolines is described Resin bound tryptophan residues or non-peptide structures carrying 3-(2-aminoethyl)indole structures react rapidly under mild reaction conditions and in high yields with aldehydes to produce C-l substituted 1,2,3,4-tetrahydro-beta-carbolines in a Pictet-Spengler reaction The method can be employed to readily produce a wide range of tetrahydro-beta-carbolines in combinatorial chemistry.

引用

页码：9211 / 9214

页数：4

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