THE CLONOGEN CONTENT OF MURINE INTESTINAL CRYPTS - DEPENDENCE ON RADIATION-DOSE USED IN ITS DETERMINATION

被引:43
作者
HENDRY, JH
ROBERTS, SA
POTTEN, CS
机构
[1] CHRISTIE HOSP & HOLT RADIUM INST,NHS TRUST,PATERSON INST CANC RES,DEPT BIOMATH & COMP,MANCHESTER M20 9BX,LANCS,ENGLAND
[2] CHRISTIE HOSP & HOLT RADIUM INST,NHS TRUST,PATERSON INST CANC RES,DEPT EPITHELIAL BIOL,MANCHESTER M20 9BX,LANCS,ENGLAND
关键词
D O I
10.2307/3578342
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The number of colony-forming (clonogenic) cells in each of the crypts in mouse small intestine was deduced using a two-dose irradiation technique. The number was 7.5 ± 0.8 cells using two equal doses each less than 9 Gy and 38 ± 7 cells using 9 Gy or more per dose. The significant dose dependence could not be accounted for by considerations of intra- or intercrypt variability, or by the factor introduced to correct the sampling frequency for the influence of crypt size. The results suggest that more colony-forming cells may be recruited when the injury is more severe.
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页码:115 / 119
页数:5
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