ANORECTIC AND NEUROCHEMICAL EFFECTS OF PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE IN RATS

被引：63

作者：

CHANCE, WT ^{[1
]}

THOMPSON, H ^{[1
]}

THOMAS, I ^{[1
]}

FISCHER, JE ^{[1
]}

机构：

[1] VET ADM MED CTR, CINCINNATI, OH 45220 USA

来源：

PEPTIDES | 1995年 / 16卷 / 08期

关键词：

NEUROPEPTIDE Y; CYCLIC AMP; ANOREXIA; ADIPSIA; NEUROTRANSMITTERS; HYPOTHALAMUS;

D O I：

10.1016/0196-9781(95)02048-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pretreatment of rats with intrahypothalamic injections of pituitary adenylate cyclase activating peptide (PACAP) 10 min prior to the injection of neuropeptide Y (NPY) significantly reduced food and water intake during the 4-h measurement period. Intrahypothalamic injection of PACAP in schedule-fed rats also reduced food and water intake for 2 h. A smaller 1-h reduction of water intake was observed in water-deprived rats, suggesting that the anticonsummatory effects of PACAP were primarily against food intake. PACAP treatment did not alter hypothalamic concentration of NPY, nor were neurotransmitters, precursors, or metabolites altered substantially in corpus striatum or nucleus accumbens regions. These results demonstrate primary anorectic effects of intrahypothalamic injection of PACAP. The demonstration of these anorectic effects may suggest a role of cyclic AMP activation and inhibition in the control of satiety and hunger.

引用

页码：1511 / 1516

页数：6

共 41 条

[1] TISSUE DISTRIBUTION OF PACAP AS DETERMINED BY RIA - HIGHLY ABUNDANT IN THE RAT-BRAIN AND TESTES [J].