STUDIES ON INTERFERON INDUCTION BY NEWCASTLE DISEASE VIRUS (NDV) .2. INTERFERON INDUCTIONS BY HEAT- AND ACID-TREATED NDV

被引：11

作者：

KOHNO, S

KOHASE, M

SHIMIZU, Y

机构：

[1] Department of Measles Virus, National Institute of Health, Murayama-Branch, Tokyo, Kitatama-gun

来源：

ARCHIV FUR DIE GESAMTE VIRUSFORSCHUNG | 1969年 / 28卷 / 02期

关键词：

D O I：

10.1007/BF01249383

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Heat- and acid-treatments of EG-NDV, which was essentially a very poor inducer of interferon in PCE cells, resulted in the development of the potency to stimulate interferon synthesis. Optimum temperature to bring about the activation was 56° C, and the peak of the potency was obtained after 4-6 minutes. Effective pH range was 1.6-2.5. Neutral and alkaline pH did not exhibit the stimulatory effect. A hypothetical mechanism to interprete the observed facts is presented, which assumes a heat- and acid-labile component in the virion inhibitory to the induction or synthesis of interferon in PCE cells. © 1969 Springer-Verlag.

引用

页码：188 / &

共 6 条

[1] METABOLIC DETERMINANTS OF INTERFERON FORMATION [J].